Endocrine Abstracts

The artificial pancreas or closed loop is the holy grail of diabetes technology. The concept has been around for decennia, but only as more or less accurate continuous glucose monitors became available some 10–15 years ago, patient related research could be initiated. The essential problem is the inherent delays in the loop. Insulin absorption, glucose uptake by the cell after activation of the insulin receptor and continuous glucose monitoring all take time. Once adminis...

Due to its rarity, initial endocrine abnormalities in acromegaly are difficult to investigate in a large cohort, especially with respect to cofounding variables. We searched the German Acromegaly Register for data on the first presentation of patients with acromegaly.Up to November 2005, 1485 patients with acromegaly had been entered into the database. Male patients demonstrated significantly higher random GH (21.0 (0.2–620.0) ng/ml, median (range))...

Immunohistochemistry is commonly performed on tumour specimen obtained during transsphenoidal surgery, but its predictive value for clinical outcome is largely unknown. The aim of this study was to compare clinical and biochemical outcome characteristics after surgery with histological tumour properties. This was achieved by matching data from the German Acromegaly Register with those of the Pituitary Tumour Registry of the German pituitary working group. From 285 out of 1543 ...